How to sell in multiple currencies?

Does anyone have any suggestions of how to sell in currencies other than their home currency?

E.g currently if we want to sell a product for £48 in America we would have to market it to the US as £48 and let the potentail customers do the exchange rate maths. We would like to be able to market the same product in the US for $50 and we deal with the exchange rates behind the scenes.

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this is a question I have been looking at and have drawn a blank. We are having to move away from the Infusionsoft shopping cart functionality.