As happens with almost every Infusionsoft upgrade, something broke. In this case we were told by support today that Action Sets are broken... across all Infusionsoft customers. Fortunately it appears to only happen in the UI, not via the API.
Seems that Action Sets are being turned off automagically, and randomly by Infusionsoft. Easy enough to fix, you just go in and turn them back on, until, of course, they mysteriously turn back off. Repeat as necessary.
Sounds like this has been broken for about a week and of course, Infusionsoft continues to think it is a good idea to be secretive about these things and force you to figure them out for yourself once your own users start complaining rather than post current status/problems anywhere so we can be proactive about it.
Bottom line... if you use Action Sets from the UI be sure to make sure your actions are actually being run.